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ForumsNutrition & SupplementationCreatine monohydrate + GLP-1 — safety and lean mass preservation data Page 2

Creatine monohydrate + GLP-1 — safety and lean mass preservation data

MikeFit_NJ Thu, Mar 12, 2026 at 9:26 PM 14 replies 346 viewsPage 2 of 3
carlos_SATX
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Mar 13, 2026 at 12:16 AM#6

Okay the water retention thing is what scares me. I weigh myself daily (I know, I know) and seeing the scale go UP would honestly send me into a spiral. My brain knows it's water but my anxiety doesn't care.

Anyone have tips for mentally handling that initial scale bump? Or should I just not weigh myself for 2 weeks when I start?

22 23james_edin, FranDenver, Dr.BariatricHTX and 19 others
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JessicaM_2024
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Portland, OR
Mar 13, 2026 at 12:33 AM#7

Honestly? Don't weigh yourself for 3 weeks when you start creatine. Or switch to weekly weigh-ins using a rolling average. The day-to-day fluctuations on creatine + GLP-1 + normal water/food variation can be like 2-3kg in either direction on any given day. It'll drive you nuts.

Better metrics while on creatine: waist circumference, how clothes fit, progress photos, lifting numbers. The scale becomes a less useful tool (it was never a great one honestly).

46 19NicoleRaleigh, james_edin, FranDenver and 43 others
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Dr.RenalNash
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Mar 13, 2026 at 12:50 AM#8

I'll play devil's advocate slightly. While creatine is safe and well-studied, I think the GLP-1 community sometimes treats it as a magic bullet for muscle preservation. It helps, yes, but the effect size is modest. The hierarchy should be:

  1. Adequate protein intake (1.2-1.6g/kg) — biggest impact
  2. Consistent resistance training with progressive overload — second biggest
  3. Adequate sleep (7-9 hrs) — often overlooked, hugely important
  4. Creatine 5g/day — helpful but marginal compared to the above

Don't add creatine while eating 60g protein and doing no exercise. Fix the foundations first.

4 21Dr.NutriCornell, pam_stl, wei_SG and 1 other
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Mar 13, 2026 at 1:07 AM#9

Totally fair hierarchy. Creatine is the cherry on top, not the cake itself. Thanks everyone for the thorough discussion — this is exactly the kind of evidence-based conversation I was hoping for. Starting 5g/day tomorrow, no loading phase, with breakfast. Will report back in a month. 💊🏋️

1 18BiostatsBrad
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