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Evidence-based GLP-1 & peptide discussion since 2023
ForumsNutrition & SupplementationDigestive enzyme supplementation — does it help with GLP-1 GI symptoms? Page 2

Digestive enzyme supplementation — does it help with GLP-1 GI symptoms?

Dr.GutHealth Sun, Feb 8, 2026 at 7:23 PM 7 replies 544 viewsPage 2 of 2
DanielChem_CHI
Senior Member
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Mar 2024
Chicago, IL
Feb 8, 2026 at 10:13 PM#6

Congrats Dr.GutHealth!! You should be so proud of yourself. 🎉

Last edited: Feb 9, 2026 at 12:13 AM
26 8fiona_VT, denise_HTX, raj_cambridge and 23 others
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andrew_nyc
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Apr 2024
New York, NY
Feb 8, 2026 at 10:30 PM#7

Clinical perspective on Digestive enzyme supplementation does:

I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.

For this specific question, I would recommend: getting comprehensive baseline labs first.

28 8Dr.NateNeph, PharmD_Rodriguez, julia.endo and 25 others
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quinn_sf
Member
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Jun 2024
San Francisco, CA
Feb 8, 2026 at 10:47 PM#8

Yep. My endo said the same thing about Digestive enzyme.

37 3mona_PHX, andrew_nyc, Dr.EndoEP and 34 others
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pam_stl
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Oct 2024
St. Louis, MO
Feb 8, 2026 at 11:04 PM#9

Reading this thread on Digestive enzyme hits close to home. Night shift nurse — I started at 287 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 62 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Digestive enzyme — take the leap. It was the best health decision I have ever made. ❤️

27 21SleepDoc_PDX, RegAffairsDC, BiostatsBrad and 24 others
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traveltech_sara
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Jan 2025
Remote, USA
Feb 8, 2026 at 11:21 PM#10
DanielChem_CHI said:
You should be so proud of yourself

This is exactly right. DanielChem_CHI articulated what I have been trying to explain to my friends for months. The Digestive enzyme aspect is what made the difference for me.

22 2BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 19 others
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