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Evidence-based GLP-1 & peptide discussion since 2023
ForumsNutrition & SupplementationFiber supplementation for GLP-1 constipation — need advice

Fiber supplementation for GLP-1 constipation — need advice

Dr.SurgeonPGH Sat, Dec 13, 2025 at 5:59 PM 6 replies 741 viewsPage 1 of 2
Dr.SurgeonPGH
Senior Member
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Mar 2024
Pittsburgh, PA
Dec 13, 2025 at 7:24 PM#1

Can I just vent for a second about fiber supplementation for glp-1 constipation need?

I know this forum is evidence-based and I love that about it, but sometimes you just need to let it out. I hit another plateau and I am frustrated.

Not looking for a fix necessarily — just solidarity. Anyone else going through this right now?

44 23DoseLogDan, SleepFixSam, PurityPaulOR and 41 others
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Dr.NateNeph
VIP Member
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Dec 2023
Houston, TX
Dec 13, 2025 at 7:41 PM#2

Dr.SurgeonPGH's experience with Fiber supplementation for resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 36 lbs in 11 months.

One thing I would add that Dr.SurgeonPGH did not mention: the relationship with food fundamentally changed.

48 9NauseaFreeNow, SteveThurs, B12Beth and 45 others
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Dr.LeslieOBGYN
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May 2024
Dallas, TX
Dec 13, 2025 at 7:58 PM#3

Thanks for sharing this, Dr.SurgeonPGH. A few questions about your Fiber supplementatio experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about Fiber supplemen?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Dec 14, 2025 at 1:58 AM
34 24james_edin, FranDenver, Dr.BariatricHTX and 31 others
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Dr.SurgeonPGH
Senior Member
1,345
6,789
Mar 2024
Pittsburgh, PA
Dec 13, 2025 at 8:15 PM#4

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Fiber supplementation for.

To answer Dr.LeslieOBGYN: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

25 21RickReta_CO, PharmHunterJen, TomTeleRx and 22 others
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hank_denver
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Sep 2024
Denver, CO
Dec 13, 2025 at 8:32 PM#5

Relevant to Fiber supplementation for — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 229 → 99 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

23 19Dr.DermMIA, fiona_VT, denise_HTX and 20 others
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