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Evidence-based GLP-1 & peptide discussion since 2023
ForumsNutrition & SupplementationProtein powder rankings — what worked for you?

Protein powder rankings — what worked for you?

Dr.EM_Chicago Fri, Nov 28, 2025 at 11:29 PM 39 replies 1,034 viewsPage 1 of 8
Dr.EM_Chicago
Member
567
2,567
May 2024
Chicago, IL
Nov 29, 2025 at 12:54 AM#1

I literally cannot with protein shakes anymore. Every single one I've tried since starting Wegovy makes me feel like I'm gonna hurl. Thick, milky, sweet — it's like my body has declared war on everything that used to taste fine.

I've tried:

  • Optimum Nutrition Gold Standard — too sweet, instant nausea
  • Premier Protein premade — the thickness is unbearable now
  • Fairlife — same thick/sweet problem
  • Some random plant-based one from Amazon — chalky AND sweet, worst combo

I need to get more protein in but solid food is also a struggle most days. Someone please tell me there's a shake out there that doesn't make GLP-1 stomachs revolt 😭

33 11jim_asheville, matt_MKE, Dr.ReproEndo and 30 others
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Dr.GutHealth
Senior Member
1,456
7,890
Mar 2024
Minnesota
Nov 29, 2025 at 1:11 AM#2

The key insight most people miss: it's not the protein that's causing nausea, it's the fat content, sweeteners, and thickness. GLP-1 meds slow gastric emptying, so thick shakes sit in your stomach like cement.

What works for the GLP-1 crowd:

  1. Isopure Zero Carb (unflavored) — mix with water, add your own fruit. No artificial sweeteners.
  2. Drink Wholesome — uses real food ingredients, no additives. Pricey but very gentle on the stomach.
  3. Clear whey isolate (MyProtein or PE Science make good ones) — these mix like juice, not milkshakes. Game changer for nausea-prone people.
  4. Bone broth protein — savory option if sweet is the problem. Ancient Nutrition makes a decent one.

Also: USE MORE WATER. If a shake calls for 8oz, use 12-16oz. Thinner = easier to tolerate. Sip slowly over 30-60 minutes, don't chug it.

45 19tyler_CSCS, VanRx_Mike, steve_okc and 42 others
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SurmountFan_IN
Member
789
3,456
May 2024
Indianapolis, IN
Nov 29, 2025 at 1:28 AM#3

CLEAR WHEY. That is the answer. I will die on this hill.

MyProtein Clear Whey Isolate in Mojito or Peach Tea flavor. Mix with cold water and ice. It literally tastes like juice. 20g protein per scoop, zero thickness, zero milky grossness. I've been on semaglutide for 11 months and this is the only protein supplement I can tolerate consistently.

Fair warning tho — the first time you see it you'll be like "this can't be protein" because it looks like Kool-Aid. Trust the process 😂

Last edited: Nov 29, 2025 at 2:28 AM
44 7traveltech_sara, AttorneyGrant, DebRD_ATL and 41 others
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DadBodDave
Member
187
923
Nov 2024
Ohio
Nov 29, 2025 at 1:45 AM#4

Clear whey??? I didn't even know that was a thing! Just looked it up and you're right, it literally looks like juice. Ordering the peach tea flavor right now.

The tip about using more water is so obvious but I never thought of it. I've been dutifully using 8oz like the label says and basically making pudding. 🤦‍♀️

Last edited: Nov 29, 2025 at 4:45 AM
21 15Dr.GastroMayo, JakeBK_lifts, DerekSJ_a1c and 18 others
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sarah_nash92
Member
712
3,123
Jun 2024
Nashville, TN
Nov 29, 2025 at 2:02 AM#5

Adding another angle — if protein shakes are consistently causing GI distress, consider that you might have developed a sensitivity to whey. GLP-1 medications change your gut motility and can unmask or worsen existing dairy sensitivities.

Non-dairy options that my clients tolerate well:

  • Egg white protein powder — highly bioavailable, very clean
  • Pea + rice protein blend — complete amino acid profile when combined
  • Collagen peptides — dissolve in anything, tasteless, BUT not a complete protein (low in tryptophan and isoleucine). Good as a supplement, not a replacement.

Also worth trying: digestive enzymes taken 15min before your shake. Specifically look for one with protease and lactase. Made a huge difference for several of my clients.

34 24KetoKyle, CanadaChris, ZaraB_AL and 31 others
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