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Evidence-based GLP-1 & peptide discussion since 2023
ForumsDosing & ProtocolsSemaglutide titration: 0.25→0.5→1.0→1.7→2.4mg optimal schedule Page 17

Semaglutide titration: 0.25→0.5→1.0→1.7→2.4mg optimal schedule

Dr.Martinez Fri, Dec 1, 2023 at 4:00 PM 408 replies 44,598 viewsPage 17 of 20
FDA_TrackerJim
Senior Member
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Feb 2024
Rockville, MD
Dec 2, 2023 at 4:05 PM#81

Want to share my personal experience related to Semaglutide titration since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 287 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 12 months later: I am down 87 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Semaglutide aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

38 23Dr.Martinez, mike_mod, SarahChen_PharmD and 35 others
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Dr.SurgeonPGH
Senior Member
1,345
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Mar 2024
Pittsburgh, PA
Dec 2, 2023 at 4:22 PM#82

Just wanted to say — for anyone reading this Semaglutide thread who is feeling discouraged: it gets better. The first few weeks are the hardest. Hang in there. 💪

Last edited: Dec 2, 2023 at 7:22 PM
21 2TomTeleRx, DoseLogDan, SleepFixSam and 18 others
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EndoResFellow
Member
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Sep 2024
Baltimore, MD
Dec 2, 2023 at 4:39 PM#83

I know this thread is old but I found it through search and wanted to add my experience with Semaglutide titration since this was the most comprehensive discussion I could find.

8 months later, the information in this thread still holds up. My results have been consistent with the data shared here.

For anyone else finding this through search: the advice here is solid. The clinical trial landscape has evolved since then.

35 15paul_denver, TinaHashiRN, robert_kc and 32 others
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mia_MS2
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Mar 2026
Ann Arbor, MI
Dec 2, 2023 at 4:56 PM#84

Just wanted to say — for anyone reading this Semaglutide thread who is feeling discouraged: it gets better. The first month are the hardest. Hang in there. 💪

Last edited: Dec 2, 2023 at 7:56 PM
14 0steve_okc, dave_SLC, FDA_TrackerJim and 11 others
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LondonLisa
Member
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Mar 2024
London, UK
Dec 2, 2023 at 5:13 PM#85

Yep. My endo said the same thing about Semaglutide.

44 8SallyK_inj, CryptoCarl, MariaRD and 41 others
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