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ForumsDosing & ProtocolsSemaglutide titration: 0.25→0.5→1.0→1.7→2.4mg optimal schedule Page 2

Semaglutide titration: 0.25→0.5→1.0→1.7→2.4mg optimal schedule

Dr.Martinez Fri, Dec 1, 2023 at 4:00 PM 408 replies 44,598 viewsPage 2 of 20
claudia_zurich
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Dec 1, 2023 at 6:50 PM#6

Quick practical note — if you're doing 0.125mg from a compounded vial, the reconstitution math matters a lot here. With a 5mg vial:

  • Add 2mL BAC water → 2.5mg/mL → 0.125mg = 0.05mL = 5 units

5 units on an insulin syringe is a very small amount — just be sure you're using a syringe with fine enough markings. A 0.3mL (30-unit) syringe will have individual unit markings and be much easier to read accurately at this volume than a full 1mL syringe.

46 12emma_london, tammy_FL, Dr.LipidDallas and 43 others
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sarah.morrison
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Dec 1, 2023 at 7:07 PM#7

Great call on the syringe. I'll order the 0.3mL ones. Thank you for the advice! 🙏

9 7roxy_nash, tony_orlando, Dr.NephBHM_UK and 6 others
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rick_sfbay
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Jan 2025
San Francisco, CA
Dec 1, 2023 at 7:24 PM#8

Good discussion. I'll just add the standard disclaimer that micro-dosing is off-label and should be done under provider supervision. We don't want anyone reading this thread and deciding to start at a random low dose without medical guidance. Your provider can factor in your full medical history, not just your weight.

Last edited: Dec 2, 2023 at 1:24 AM
36 3james_edin, FranDenver, Dr.BariatricHTX and 33 others
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