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ForumsDosing & ProtocolsSteady-state concentrations across dose tiers — modeling data Page 4

Steady-state concentrations across dose tiers — modeling data

SarahChen_PharmD Tue, Mar 10, 2026 at 10:13 PM 23 replies 323 viewsPage 4 of 5
julia.endo
Senior Member
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Feb 2024
Cincinnati, OH
Mar 11, 2026 at 3:53 AM#16

Congrats Dr.CardioMD!! You should be so proud of yourself. 🎉 👏

Last edited: Mar 11, 2026 at 9:53 AM
16 15anna.melb_AU, mark_tokyo, hans_munich and 13 others
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JakeBK_lifts
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Jul 2024
Brooklyn, NY
Mar 11, 2026 at 4:10 AM#17

B12Beth — that is really helpful context on Steady-state. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

4 20JennaRN, LabKate, kate.chem and 1 other
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tommy_boulder
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Nov 2024
Boulder, CO
Mar 11, 2026 at 4:27 AM#18

Want to share my personal experience related to Steady-state concentrations since I think it might help others in a similar situation.

I started my GLP-1 journey in October 2024 at 259 lbs with prediabetes and hypertension. My endocrinologist prescribed semaglutide 0.25mg to start.

Now, 14 months later: I am down 44 lbs, my labs have normalized, and I am off 2 of my 3 medications. The Steady-state aspect specifically was something that made a big difference in my journey.

This community helped me every step of the way.

35 6robert_kc, dan_philly, MeganSA_TX and 32 others
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steph_laguna
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234
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Nov 2024
Laguna Beach, CA
Mar 11, 2026 at 4:44 AM#19

Just wanted to say — for anyone reading this Steady-state thread who is feeling discouraged: it gets better. The first month are the hardest. Hang in there. 💪

42 24DanielChem_CHI, marco_milano, pam_columbus and 39 others
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pete_nash
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Aug 2024
Nashville, TN
Mar 11, 2026 at 5:01 AM#20

100%. My provider said the same thing about Steady-state.

Last edited: Mar 11, 2026 at 11:01 AM
3 12sarah.morrison, NeuroNate, JessicaH_TX
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