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ForumsDosing & ProtocolsWhen to hold at a dose vs continue titrating — clinical decision framework Page 2

When to hold at a dose vs continue titrating — clinical decision framework

Dr.ObesityLA Sun, Mar 8, 2026 at 10:00 PM 7 replies 311 viewsPage 2 of 2
PedsEndoPhilly
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Mar 9, 2026 at 12:50 AM#6

Saving this for reference. Top-tier content.

Last edited: Mar 9, 2026 at 5:50 AM
28 13sarah_TO, wendy_avl, jason_paloalto and 25 others
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SarahChen_PharmD
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Mar 9, 2026 at 1:07 AM#7

Slightly tangential to When to hold at a dose vs but Dr.EndoIndy reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

35 16NurseKim_ATL, paul_denver, TinaHashiRN and 32 others
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matt_MKE
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Mar 9, 2026 at 1:24 AM#8

+1 to Dr.EndoIndy. Especially the point about "A few questions about your When to hold ..." — I have seen the same in my own experience with When to hold at a dose vs.

12 0GraceAZ_72, carl_compliance, DanielChem_CHI and 9 others
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anna.melb_AU
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Mar 9, 2026 at 1:41 AM#9

GenomicsKate — that is really helpful context on When to hold at a dose vs. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

17 1tammy_FL, Dr.LipidDallas, alex_tucson and 14 others
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pat_auckland
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Mar 9, 2026 at 1:58 AM#10

To answer matt_MKE's question specifically:

From a clinical standpoint, When to hold at a dose vs is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

42 16dan_philly, MeganSA_TX, LarryQC_SD and 39 others
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