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ForumsDosing & ProtocolsSplitting doses — twice-weekly semaglutide micro-dosing protocol Page 2

Splitting doses — twice-weekly semaglutide micro-dosing protocol

Dr.ObesityMed Fri, Mar 6, 2026 at 9:51 AM 17 replies 472 viewsPage 2 of 4
PharmacoVig_BOS
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Mar 6, 2026 at 12:41 PM#6

Quick practical note — if you're doing 0.125mg from a compounded vial, the reconstitution math matters a lot here. With a 5mg vial:

  • Add 2mL BAC water → 2.5mg/mL → 0.125mg = 0.05mL = 5 units

5 units on an insulin syringe is a very small amount — just be sure you're using a syringe with fine enough markings. A 0.3mL (30-unit) syringe will have individual unit markings and be much easier to read accurately at this volume than a full 1mL syringe.

30 12amsterdam_pete, LondonLisa, mike_nyc and 27 others
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wendy_avl
Member
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Oct 2024
Asheville, NC
Mar 6, 2026 at 12:58 PM#7

Great call on the syringe. I'll order the 0.3mL ones. Thank you for the advice! 🙏

Last edited: Mar 6, 2026 at 6:58 PM
48 2DoseLogDan, SleepFixSam, PurityPaulOR and 45 others
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LabKate
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Mar 6, 2026 at 1:15 PM#8

Good discussion. I'll just add the standard disclaimer that micro-dosing is off-label and should be done under provider supervision. We don't want anyone reading this thread and deciding to start at a random low dose without medical guidance. Your provider can factor in your full medical history, not just your weight.

Last edited: Mar 6, 2026 at 4:15 PM
50 1Dr.SleepRoch, laura_annarbor, JenMemphis and 47 others
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