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ForumsDosing & ProtocolsSplitting doses — twice-weekly semaglutide micro-dosing protocol Page 4

Splitting doses — twice-weekly semaglutide micro-dosing protocol

Dr.ObesityMed Fri, Mar 6, 2026 at 9:51 AM 17 replies 472 viewsPage 4 of 4
Dr.ObesityMed
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Mar 6, 2026 at 3:31 PM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Splitting doses .

To answer PharmHunterJen: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Last edited: Mar 6, 2026 at 9:31 PM
15 24EndoResFellow, PharmacoVig_BOS, SurmountFan_IN and 12 others
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Dr.NateNeph
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Mar 6, 2026 at 3:48 PM#17

Adding my data to this Splitting doses discussion:

MetricBaselineMonth 3Month 8
Weight274 lbs224 lbs219 lbs
A1C6.8%5.8%5.4%
hsCRP8.02.00.8

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

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kate.chem
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Mar 6, 2026 at 4:05 PM#18

Agreed. My doctor said the same thing about Splitting doses .

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DataDave
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Mar 6, 2026 at 4:22 PM#19

Slightly tangential to Splitting doses but TrialTracker_MD reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Mar 6, 2026 at 5:22 PM
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sarah_nash92
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Mar 6, 2026 at 4:39 PM#20

+1 to Dr.ObesityMed. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with Splitting doses .

40 0KetoKyle, CanadaChris, ZaraB_AL and 37 others
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