kevin_tulsa — that is really helpful context on Tirzepatide titration. Follow-up question: did you change anything about your diet at the same time?
I am in a similar situation (month 2) and trying to set realistic expectations.
To answer AussieAnna's question specifically:
From a clinical standpoint, Tirzepatide titration is well-supported by the literature.
The short answer: follow the standard titration protocol and reassess at 4-6 weeks.
The longer answer involves pharmacokinetic considerations around steady-state concentrations, which I am happy to elaborate on if helpful.
emma_london — wow. This community is amazing.
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View ResultsAdding my data to this Tirzepatide titration discussion:
| Metric | Baseline | Month 5 | Month 8 |
|---|---|---|---|
| Weight | 274 lbs | 219 lbs | 209 lbs |
| A1C | 6.8% | 6.0% | 5.4% |
| hsCRP | 8.0 | 4.0 | 0.8 |
Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.
Slightly tangential to Tirzepatide titration but emma_london reminded me — does anyone have experience combining this with metformin?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.