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ForumsDosing & ProtocolsDe-escalation protocols — tapering GLP-1 dose for maintenance Page 2

De-escalation protocols — tapering GLP-1 dose for maintenance

Dr.ObesityLA Mon, Feb 23, 2026 at 9:43 PM 9 replies 454 viewsPage 2 of 2
Dr.PeteFamMed
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Feb 24, 2026 at 12:33 AM#6

Saving this for reference. Top-tier content.

47 12hyun_seoul, jim_asheville, matt_MKE and 44 others
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Dr.NateNeph
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Feb 24, 2026 at 12:50 AM#7

Slightly tangential to De-escalation protocols but adam_van reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

34 24NauseaFreeNow, SteveThurs, B12Beth and 31 others
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Dr.AddMedPHL
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Feb 24, 2026 at 1:07 AM#8

+1 to adam_van. Especially the point about "A few questions about your De-escalation..." — I have seen the same in my own experience with De-escalation protocols .

Last edited: Feb 24, 2026 at 3:07 AM
12 15mike.trainer_LA, sarah_nash92, FitDadDave and 9 others
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MounjBrad
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Feb 24, 2026 at 1:24 AM#9

pete_nash — that is really helpful context on De-escalation protocols . Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

Last edited: Feb 24, 2026 at 6:24 AM
44 11pam_columbus, nick_SD_fit, ben_calgary and 41 others
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Dr.EM_Chicago
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Feb 24, 2026 at 1:41 AM#10

To answer Dr.AddMedPHL's question specifically:

From a clinical standpoint, De-escalation protocols is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

Last edited: Feb 24, 2026 at 5:41 AM
23 2lisa_labSD, adam_van, Dr.SurgeonPGH and 20 others
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