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ForumsDosing & ProtocolsMicro-dosing semaglutide — 12 month update Page 2

Micro-dosing semaglutide — 12 month update

FDA_TrackerJim Tue, Jan 20, 2026 at 10:57 AM 17 replies 874 viewsPage 2 of 4
SandraNC_45
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Sep 2024
Charlotte, NC
Jan 20, 2026 at 1:47 PM#6

Quick practical note — if you're doing 0.125mg from a compounded vial, the reconstitution math matters a lot here. With a 5mg vial:

  • Add 2mL BAC water → 2.5mg/mL → 0.125mg = 0.05mL = 5 units

5 units on an insulin syringe is a very small amount — just be sure you're using a syringe with fine enough markings. A 0.3mL (30-unit) syringe will have individual unit markings and be much easier to read accurately at this volume than a full 1mL syringe.

Last edited: Jan 20, 2026 at 6:47 PM
21 18FranDenver, Dr.BariatricHTX, LindaRN_retired and 18 others
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tommy_boulder
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Nov 2024
Boulder, CO
Jan 20, 2026 at 2:04 PM#7

Great call on the syringe. I'll order the 0.3mL ones. Thank you for the advice! 🙏

Last edited: Jan 20, 2026 at 3:04 PM
26 15TinaHashiRN, robert_kc, dan_philly and 23 others
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FranDenver
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Oct 2024
Denver, CO
Jan 20, 2026 at 2:21 PM#8

Good discussion. I'll just add the standard disclaimer that micro-dosing is off-label and should be done under provider supervision. We don't want anyone reading this thread and deciding to start at a random low dose without medical guidance. Your provider can factor in your full medical history, not just your weight.

Last edited: Jan 20, 2026 at 8:21 PM
47 6BariatricNurseD, MASHdoc_SA, GenomicsKate and 44 others
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