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ForumsDosing & ProtocolsMicro-dosing semaglutide — 12 month update Page 3

Micro-dosing semaglutide — 12 month update

FDA_TrackerJim Tue, Jan 20, 2026 at 10:57 AM 17 replies 874 viewsPage 3 of 4
gary_naperville
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Jan 20, 2026 at 3:12 PM#11

Thank you labquiet_amy! This is incredibly helpful. Taking this to my next appointment. 🙏

1 21SleepFixSam
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kate.chem
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Jan 20, 2026 at 3:29 PM#12

Slightly tangential to Micro-dosing semaglutide but FDA_TrackerJim reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

13 2VanRx_Mike, steve_okc, dave_SLC and 10 others
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PharmHunterJen
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Jul 2024
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Jan 20, 2026 at 3:46 PM#13

Thanks for sharing this, FDA_TrackerJim. A few questions about your Micro-dosing experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about Micro-dosing?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

11 23kevin_tulsa, Dr.PainCLE, mike_mealprep and 8 others
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FDA_TrackerJim
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Rockville, MD
Jan 20, 2026 at 4:03 PM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Micro-dosing semaglutide .

To answer kate.chem: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

42 19Dr.LeslieOBGYN, MikeNYC_runner and 39 others
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Dr.PathRoch
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Jun 2024
Rochester, MN
Jan 20, 2026 at 4:20 PM#15

Adding my data to this Micro-dosing semaglutide discussion:

MetricBaselineMonth 3Month 8
Weight254 lbs234 lbs219 lbs
A1C6.8%5.8%5.4%
hsCRP8.02.01.2

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

Last edited: Jan 20, 2026 at 10:20 PM
1 14Dr.MetabolicMD
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