Jan 5, 2026 at 2:38 AM#6
Subscribing to this thread. Half-life implications is exactly what I've been researching. 🙏
Last edited: Jan 5, 2026 at 5:38 AM
34 23Dr.LeslieOBGYN, MikeNYC_runner and 31 others
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Jan 5, 2026 at 2:55 AM#7
OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Half-life implications.
To answer KevinCompounds: I started tracking everything in a spreadsheet from day 1.
Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
10 13Dr.EndoEP, GraceAZ_72, carl_compliance and 7 others
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Jan 5, 2026 at 3:12 AM#8
Adding my data to this Half-life implications discussion:
| Metric | Baseline | Month 4 | Month 8 |
|---|---|---|---|
| Weight | 270 lbs | 245 lbs | 205 lbs |
| A1C | 6.4% | 6.2% | 5.4% |
| hsCRP | 4.0 | 3.0 | 1.2 |
Protocol: Tirzepatide 15mg/wk, resistance training 3x/wk, protein 1.2g/kg/day.
29 1FranDenver, Dr.BariatricHTX, LindaRN_retired and 26 others
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View ResultsJan 5, 2026 at 3:29 AM#9
+1 to matt_MKE. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with Half-life implications.
Last edited: Jan 5, 2026 at 9:29 AM
25 3Dr.MetabolicMD, RetaRick_CA, JenPlateau and 22 others
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Jan 5, 2026 at 3:46 AM#10
Slightly tangential to Half-life implications but hannah_MT reminded me — has anyone else noticed changes in their alcohol tolerance?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
10 7marcus_mpls, DeniseRN_TPA, SandraNC_45 and 7 others
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