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ForumsPharmacology & MechanismsBiased agonism at GLP-1R — Gs vs β-arrestin signaling balance Page 3

Biased agonism at GLP-1R — Gs vs β-arrestin signaling balance

PeptideChemSF Fri, Mar 13, 2026 at 1:59 AM 13 replies 263 viewsPage 3 of 3
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Mar 13, 2026 at 6:14 AM#11

Moderator note: Great discussion, everyone. Just a reminder to keep things civil and evidence-based.

Thread quality is excellent — keep it up. 👍

Last edited: Mar 13, 2026 at 10:14 AM
4 7PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 1 other
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COA_Karl
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Mar 13, 2026 at 6:31 AM#12

Slightly tangential to Biased agonism at GLP-1R but Dr.NutriCornell reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

21 9jim_asheville, matt_MKE, Dr.ReproEndo and 18 others
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ingrid_STO
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Mar 13, 2026 at 6:48 AM#13
newstart_MO said:
Follow-up question: what labs did your doctor order to monitor this

This is exactly right. newstart_MO articulated what I have been trying to explain to my friends for months. The Biased agonism at GLP-1R aspect is what made the difference for me.

49 18MikeFit_NJ, InsuranceTom, WendyG_ATL and 46 others
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TirzTom
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Mar 13, 2026 at 7:05 AM#14

Saving this for reference. Quality thread.

48 10SandraNC_45, Dr.EndoIndy, tom_AK and 45 others
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lisa_labSD
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Mar 13, 2026 at 7:22 AM#15

Adding my data to this Biased agonism at GLP-1R discussion:

MetricBaselineMonth 5Month 6
Weight268 lbs218 lbs203 lbs
A1C7.2%6.0%5.2%
hsCRP7.04.01.0

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.5g/kg/day.

Last edited: Mar 13, 2026 at 10:22 AM
3 19cory_ATX, lori_vegas, Dr.PulmRoch
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