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ForumsPharmacology & MechanismsGlucagon receptor signaling — hepatic glycogenolysis and lipolysis Page 3

Glucagon receptor signaling — hepatic glycogenolysis and lipolysis

Dr.MetabolicMD Thu, Mar 12, 2026 at 2:56 AM 16 replies 226 viewsPage 3 of 4
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Mar 12, 2026 at 7:11 AM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

45 13PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 42 others
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DanielChem_CHI
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Mar 12, 2026 at 7:28 AM#12

Slightly tangential to Glucagon receptor but BethLabQueen reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

42 4Dr.DermMIA, fiona_VT, denise_HTX and 39 others
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TrialNerd_Beth
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Mar 12, 2026 at 7:45 AM#13
NicoleRaleigh said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. NicoleRaleigh articulated what I have been trying to explain to my doctor for months. The Glucagon receptor aspect is the most important factor.

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labquiet_amy
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Mar 12, 2026 at 8:02 AM#14

Saving this for reference. Top-tier content.

Last edited: Mar 12, 2026 at 10:02 AM
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dan_philly
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Mar 12, 2026 at 8:19 AM#15

Adding my data to this Glucagon receptor discussion:

MetricBaselineMonth 4Month 8
Weight266 lbs226 lbs211 lbs
A1C7.0%6.2%5.4%
hsCRP5.03.00.8

Protocol: Tirzepatide 15mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

46 8EndoResFellow, PharmacoVig_BOS, SurmountFan_IN and 43 others
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