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Evidence-based GLP-1 & peptide discussion since 2023
ForumsDosing & ProtocolsWeekend vs weekday injection — 12 month update Page 5

Weekend vs weekday injection — 12 month update

Admin Fri, Nov 7, 2025 at 3:42 PM 37 replies 1,305 viewsPage 5 of 8
PeptideSynthNJ
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Nov 7, 2025 at 10:47 PM#21

Congrats Admin!! Keep going — you're doing incredible. 🎉

Last edited: Nov 8, 2025 at 2:47 AM
39 15wanda_boise, NurseAsh_DET, BenResearch_OR and 36 others
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BenResearch_OR
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Dec 2023
Oregon
Nov 7, 2025 at 11:04 PM#22

Reading this thread on Weekend vs weekday hits close to home. Night shift nurse — I started at 283 lbs and felt like I would tried everything.

9 months on tirz and I am a different person. Not just the 58 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Weekend vs weekday — take the leap. It was the best health decision I have ever made. ❤️

Last edited: Nov 8, 2025 at 12:04 AM
33 3PharmD_Rodriguez, julia.endo, JessicaM_2024 and 30 others
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Dr.Martinez
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Nov 7, 2025 at 11:21 PM#23

As a pharmacist, I want to add some clinical context to this discussion on Weekend vs weekday injection 12 month.

Building on what PeptideSynthNJ said — the evidence base here is robust. The key publications to reference are from the FLOW program[1].

Key clinical points:

  1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
  2. Side effect profile is predictable and usually manageable with standard protocols
  3. Monitoring should include baseline labs and follow-up at 3-month intervals
  4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

References:
[1] See thread title for relevant study identification.
5 1rachel_ABQ, traveltech_sara, AttorneyGrant and 2 others
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quinn_sf
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Jun 2024
San Francisco, CA
Nov 7, 2025 at 11:38 PM#24

BenResearch_OR — wow. I've been looking for this exact info for weeks.

Last edited: Nov 8, 2025 at 5:38 AM
50 1andrew_nyc, Dr.EndoEP, GraceAZ_72 and 47 others
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labquiet_amy
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Nov 7, 2025 at 11:55 PM#25

Adding my data to this Weekend vs weekday discussion:

MetricBaselineMonth 5Month 6
Weight276 lbs236 lbs221 lbs
A1C7.0%6.0%5.2%
hsCRP5.04.01.0

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.

34 6pete_manc_UK, anna.melb_AU, mark_tokyo and 31 others
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