Tachyphylaxis vs tolerance — pharmacological distinction on GLP-1 — Page 3

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Mar 10, 2026 at 5:16 AM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

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TirzTom

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Mar 10, 2026 at 5:33 AM#12

Slightly tangential to Tachyphylaxis vs but Dr.GutHealth reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Last edited: Mar 10, 2026 at 9:33 AM

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sarah_TO

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Mar 10, 2026 at 5:50 AM#13

TinaHashiRN said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. TinaHashiRN articulated what I have been trying to explain to my doctor for months. The Tachyphylaxis vs aspect is the most important factor.

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