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Evidence-based GLP-1 & peptide discussion since 2023
ForumsDosing & ProtocolsDe-escalation protocols — January 2024 Page 2

De-escalation protocols — January 2024

KevinCompounds Sat, Nov 1, 2025 at 11:37 PM 6 replies 838 viewsPage 2 of 2
pete_manc_UK
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Nov 2, 2025 at 2:27 AM#6
LipidDoc_ATL said:
For De-escalation protocols January, here is what the evidence says:The clinical trial data (SURMOU

Gonna push back on this one. De-escalation protocols January is not that straightforward in my experience. I have been on this for 12 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But cost accessibility is a real barrier. We should be honest about that.

Last edited: Nov 2, 2025 at 8:27 AM
23 14TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 20 others
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Dr.AddMedPHL
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Philadelphia, PA
Nov 2, 2025 at 2:44 AM#7

Adding my data to this De-escalation protocols discussion:

MetricBaselineMonth 4Month 6
Weight244 lbs239 lbs199 lbs
A1C6.8%6.2%5.2%
hsCRP8.03.01.0

Protocol: Tirzepatide 15mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

Last edited: Nov 2, 2025 at 4:44 AM
50 11sarah_nash92, FitDadDave, RunnerRach and 47 others
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TomTeleRx
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Nov 2, 2025 at 3:01 AM#8

Dr.EndoEP — wow. This community is amazing.

Last edited: Nov 2, 2025 at 4:01 AM
45 15LibrarianMeg, bri_stats, pete_manc_UK and 42 others
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emily_PDX
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Nov 2024
Portland, OR
Nov 2, 2025 at 3:18 AM#9

Slightly tangential to De-escalation protocols but GraceAZ_72 reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

30 13Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 27 others
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mike_mod
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Nov 2, 2025 at 3:35 AM#10

Moderator note: Please keep vendor-specific discussions in the Vendor Reviews section.

I have cleaned up a few off-topic posts. 👍

Last edited: Nov 2, 2025 at 5:35 AM
28 17PurityPaulOR, MaxMetOK, MounjBrad and 25 others
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