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ForumsDosing & ProtocolsDrawing from a multi-dose vial — what worked for you?

Drawing from a multi-dose vial — what worked for you?

Dr.GutHealth Mon, Oct 27, 2025 at 4:33 AM 15 replies 918 viewsPage 1 of 3
Dr.GutHealth
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Oct 27, 2025 at 5:58 AM#1

Drawing from a multi-dose vial — what worked for you?

Saw this come across my feed today and thought the community would want to discuss.

Drawing from a multi-dose vial what is something that affects a lot of us here, and the latest information is worth paying attention to. I'll share what I know and hopefully others can fill in the gaps.

Key points as I understand them:

  • This has been evolving over the past few months
  • There are different perspectives on how to approach it
  • The practical implications depend on your specific situation

What are you all hearing from your providers about this? Anyone have direct experience to share?

37 8VanRx_Mike, steve_okc, dave_SLC and 34 others
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MikeFit_NJ
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Apr 2024
New Jersey
Oct 27, 2025 at 6:15 AM#2

Dr.GutHealth's experience with Drawing from a multi-dose resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 64 lbs in 9 months.

One thing I would add that Dr.GutHealth did not mention: the relationship with food fundamentally changed.

15 9marcus_mpls, DeniseRN_TPA, SandraNC_45 and 12 others
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lori_vegas
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Aug 2024
Las Vegas, NV
Oct 27, 2025 at 6:32 AM#3

Thanks for sharing this, Dr.GutHealth. A few questions about your Drawing from a experience:

  1. What dose worked best for you?
  2. How long before you noticed appetite suppression kicking in?
  3. Did your endo have any specific recommendations about Drawing from a?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Oct 27, 2025 at 8:32 AM
39 6oliver_london, tane_welly, Dr.PathRoch and 36 others
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Dr.GutHealth
Senior Member
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Mar 2024
Minnesota
Oct 27, 2025 at 6:49 AM#4

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Drawing from a multi-dose.

To answer lori_vegas: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

20 12Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 17 others
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jason_paloalto
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Oct 27, 2025 at 7:06 AM#5

Relevant to Drawing from a multi-dose vial — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 197 → 97 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

2 10Dr.EndoEP, GraceAZ_72
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