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ForumsDosing & ProtocolsPK/PD modeling for tirzepatide — anyone have experience? Page 2

PK/PD modeling for tirzepatide — anyone have experience?

CryptoCarl Wed, Oct 15, 2025 at 5:27 AM 24 replies 1,368 viewsPage 2 of 5
CryptoCarl
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Oct 15, 2025 at 8:17 AM#6

Nate — 1,200 cal/day is definitely too low, especially if you're male. Please talk to your provider or a dietitian. Under-eating on GLP-1s can cause muscle loss and metabolic adaptation that'll hurt you long-term. We want fat loss, not just weight loss. 💪

Last edited: Oct 15, 2025 at 12:17 PM
49 17CryptoCarl, MariaRD, AussieAnna and 46 others
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RetaRick_CA
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Oct 15, 2025 at 8:34 AM#7

The energy thing is real and I think it's one of the most underreported benefits of tirz. I track my workouts religiously and my performance has IMPROVED since starting, despite being in a caloric deficit. My lifting numbers went up. That should not happen when you're eating less. There's definitely something pharmacological going on beyond just "eating better."

I've seen some hypotheses that GIP receptor activation in muscle tissue may help preserve or even improve muscle glucose utilization during weight loss. Would love to see more research on this.

1 3AmyNC_wife
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Dr.ObesityLA
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Oct 15, 2025 at 8:51 AM#8

Fran that's fascinating. I'm not lifting (yet) but I might start — the energy has to go somewhere right? 😂

Thanks everyone for confirming I'm not losing my mind. Just losing weight and gaining energy. I'll take it!

39 19tampaLisa73, KarenAZ_mom, zoe_NC and 36 others
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