Reading this thread on PK/PD modeling for hits close to home. Dad of 2 checking in — I started at 285 lbs and felt like I would tried everything.

11 months on tirz and I am a different person. Not just the 60 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about PK/PD modeling for — take the leap. It was the best health decision I have ever made. ❤️

Moderator note: Great discussion, everyone. Just a reminder to keep things civil and evidence-based.

Thread quality is excellent — keep it up. 👍

Relevant to PK/PD modeling for tirzepatide — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 237 → 107 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Thank you NurseAsh_DET! This is incredibly helpful. Taking this to my next appointment. 🙏

+1 to Dr.EM_Chicago. Especially the point about "PK/PD modeling for is exactly what I've ..." — I have seen the same in my own experience with PK/PD modeling for.