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ForumsPharmacology & MechanismsIncretin effect in healthy vs T2DM — why GLP-1 response is blunted in diabetes Page 3

Incretin effect in healthy vs T2DM — why GLP-1 response is blunted in diabetes

Dr.MetabolicMD Fri, Feb 27, 2026 at 12:30 AM 13 replies 471 viewsPage 3 of 3
patPC_UT
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Feb 27, 2026 at 4:45 AM#11

100%. My provider said the same thing about Incretin effect in.

34 0sarah_nash92, FitDadDave, RunnerRach and 31 others
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SarahChen_PharmD
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San Diego, CA
Feb 27, 2026 at 5:02 AM#12

Reading this thread on Incretin effect in hits close to home. Dad of 2 checking in — I started at 273 lbs and felt like I would tried everything.

9 months on tirz and I am a different person. Not just the 48 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Incretin effect in — take the leap. It was the best health decision I have ever made. ❤️

Last edited: Feb 27, 2026 at 8:02 AM
29 17NurseKim_ATL, paul_denver, TinaHashiRN and 26 others
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Admin
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Feb 27, 2026 at 5:19 AM#13

Moderator note: Great discussion, everyone. Just a reminder to keep things civil and evidence-based.

Thread quality is excellent — keep it up. 👍

27 8RegAffairsDC, BiostatsBrad, PeptideSynthNJ and 24 others
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Dr.GutHealth
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Feb 27, 2026 at 5:36 AM#14

Relevant to Incretin effect in healthy vs — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 245 → 115 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

15 0Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 12 others
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LarryQC_SD
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Feb 27, 2026 at 5:53 AM#15

Congrats patPC_UT!! You should be so proud of yourself. 🎉

Last edited: Feb 27, 2026 at 6:53 AM
41 5dan_philly, MeganSA_TX, LarryQC_SD and 38 others
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