Putting together a summary on my doctor says stay on 1mg since I keep seeing the same questions pop up.

I am not a medical professional (just a well-researched patient) so take this with appropriate salt, but I have compiled info from the clinical trials.

Happy to be corrected by the actual clinicians here — that is the whole point of posting it.

Dr.KarenChen's experience with My doctor says stay on resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 40 lbs in 5 months.

One thing I would add that Dr.KarenChen did not mention: the relationship with food fundamentally changed.

Thanks for sharing this, Dr.KarenChen. A few questions about your My doctor says stay experience:

1. What dose worked best for you?
2. How long before you noticed appetite suppression kicking in?
3. Did your endo have any specific recommendations about My doctor says?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on My doctor says stay on.

To answer Dr.DermMIA: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Relevant to My doctor says stay on 1mg but — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 233 → 103 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.