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ForumsPharmacology & MechanismsStructure-function of tirzepatide — unimolecular dual agonist design Page 3

Structure-function of tirzepatide — unimolecular dual agonist design

PeptideChemSF Mon, Feb 23, 2026 at 12:31 AM 14 replies 437 viewsPage 3 of 3
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Feb 23, 2026 at 4:46 AM#11

Moderator note: Great discussion, everyone. Just a reminder to keep things civil and evidence-based.

Thread quality is excellent — keep it up. 👍

Last edited: Feb 23, 2026 at 8:46 AM
35 10PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 32 others
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COA_Karl
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Feb 23, 2026 at 5:03 AM#12

Slightly tangential to Structure-function of but julia.endo reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

6 22jim_asheville, matt_MKE, Dr.ReproEndo and 3 others
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MarkLI_maint
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Feb 23, 2026 at 5:20 AM#13
hans_munich said:
Follow-up question: what labs did your doctor order to monitor this

This is exactly right. hans_munich articulated what I have been trying to explain to my friends for months. The Structure-function of aspect is what made the difference for me.

33 13HPLC_Greg, LibrarianMeg, bri_stats and 30 others
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Janoshik Analytical — Independent Testing

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tane_welly
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Feb 23, 2026 at 5:37 AM#14

Saving this for reference. Quality thread.

40 0marco_milano, pam_columbus, nick_SD_fit and 37 others
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lucas_SP_BR
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Feb 23, 2026 at 5:54 AM#15

Adding my data to this Structure-function of discussion:

MetricBaselineMonth 5Month 6
Weight260 lbs230 lbs215 lbs
A1C6.4%6.0%5.2%
hsCRP4.04.01.0

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.2g/kg/day.

Last edited: Feb 23, 2026 at 7:54 AM
40 3tampaLisa73, KarenAZ_mom, zoe_NC and 37 others
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