Dr.AddMedPHL said:

For Why does it stop working after a, here is what the evidence says:The clinical trial data (SELECT

Gonna push back on this one. Why does it stop working after a is not that straightforward in my experience. I have been on this for 18 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But adherence is harder than people admit. We should be honest about that.

Adding my data to this Why does it stop working discussion:

Protocol: Tirzepatide 15mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

Dr.CardioMD — wow. I've been looking for this exact info for weeks.

Slightly tangential to Why does it stop working but fiona_VT reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Moderator note: This thread has been getting great engagement. Please remember to cite sources when making clinical claims.

No issues to report — carry on. 👍