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ForumsDosing & ProtocolsHas anyone dealt with micro-dosing semaglutide? Page 2

Has anyone dealt with micro-dosing semaglutide?

KarenAZ_mom Sat, Aug 16, 2025 at 5:41 AM 18 replies 1,254 viewsPage 2 of 4
PeptideSynthNJ
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Aug 2024
Princeton, NJ
Aug 16, 2025 at 8:31 AM#6

Quick practical note — if you're doing 0.125mg from a compounded vial, the reconstitution math matters a lot here. With a 5mg vial:

  • Add 2mL BAC water → 2.5mg/mL → 0.125mg = 0.05mL = 5 units

5 units on an insulin syringe is a very small amount — just be sure you're using a syringe with fine enough markings. A 0.3mL (30-unit) syringe will have individual unit markings and be much easier to read accurately at this volume than a full 1mL syringe.

1 23wanda_boise
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fiona_glasgow
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Aug 2024
Glasgow, UK
Aug 16, 2025 at 8:48 AM#7

Great call on the syringe. I'll order the 0.3mL ones. Thank you for the advice! 🙏

50 7TirzTom, TrialTracker_MD, JennaRN and 47 others
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labquiet_amy
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Cambridge, MA
Aug 16, 2025 at 9:05 AM#8

Good discussion. I'll just add the standard disclaimer that micro-dosing is off-label and should be done under provider supervision. We don't want anyone reading this thread and deciding to start at a random low dose without medical guidance. Your provider can factor in your full medical history, not just your weight.

1 3LibrarianMeg
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