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ForumsDosing & ProtocolsSemaglutide PK modeling — need advice Page 2

Semaglutide PK modeling — need advice

Dr.RaviCardio Fri, Aug 1, 2025 at 12:53 PM 7 replies 1,070 viewsPage 2 of 2
SleepDoc_PDX
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Sep 2024
Portland, OR
Aug 1, 2025 at 3:43 PM#6

Quick practical note — if you're doing 0.125mg from a compounded vial, the reconstitution math matters a lot here. With a 5mg vial:

  • Add 2mL BAC water → 2.5mg/mL → 0.125mg = 0.05mL = 5 units

5 units on an insulin syringe is a very small amount — just be sure you're using a syringe with fine enough markings. A 0.3mL (30-unit) syringe will have individual unit markings and be much easier to read accurately at this volume than a full 1mL syringe.

Last edited: Aug 1, 2025 at 6:43 PM
26 7pete_nash, hank_denver, carlos_SATX and 23 others
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lori_vegas
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Aug 2024
Las Vegas, NV
Aug 1, 2025 at 4:00 PM#7

Great call on the syringe. I'll order the 0.3mL ones. Thank you for the advice! 🙏

4 18bbq_ray_KC, oliver_london, tane_welly and 1 other
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wanda_boise
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Aug 2024
Boise, ID
Aug 1, 2025 at 4:17 PM#8

Good discussion. I'll just add the standard disclaimer that micro-dosing is off-label and should be done under provider supervision. We don't want anyone reading this thread and deciding to start at a random low dose without medical guidance. Your provider can factor in your full medical history, not just your weight.

Last edited: Aug 1, 2025 at 9:17 PM
32 17pam_columbus, nick_SD_fit, ben_calgary and 29 others
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