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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMetabolic Health & DiabetesAdiponectin and leptin changes on GLP-1 therapy Page 2

Adiponectin and leptin changes on GLP-1 therapy

DataDave Tue, Mar 10, 2026 at 8:47 AM 15 replies 341 viewsPage 2 of 3
DerekSJ_a1c
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Aug 2024
San Jose, CA
Mar 10, 2026 at 11:37 AM#6

The sleep piece resonates hard with me. I'm a nurse doing 12-hour night shifts and my weight loss has been slower than most people I see posting here. I average about 5 hours of broken sleep on work days. I wonder how much that's holding me back.

28 12adam_van, Dr.SurgeonPGH, rachel_ABQ and 25 others
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Dr.EM_Chicago
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May 2024
Chicago, IL
Mar 10, 2026 at 11:54 AM#7

Sleep deprivation is enormously underappreciated as a factor in weight management. There are studies showing that people in a caloric deficit who sleep 5.5 hours lose 55% less fat and 60% more lean mass compared to those sleeping 8.5 hours — same caloric intake. Shift workers consistently show higher rates of obesity, metabolic syndrome, and cardiovascular disease, and disrupted circadian rhythm is a major contributor.

I know you can't always control your schedule, but even small improvements — blackout curtains, consistent wake times on days off, limiting caffeine 8+ hours before sleep — can help.

Last edited: Mar 10, 2026 at 3:54 PM
28 3matt_MKE, Dr.ReproEndo, lucas_SP_BR and 25 others
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lisa_labSD
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Oct 2024
San Diego, CA
Mar 10, 2026 at 12:11 PM#8

Looking at the OP's numbers from a trends perspective: the "plateau" from week 14-19 actually shows a slight downward trend if you plot it. 222 → 219 over 5 weeks is about 0.6 lbs/week. That's not zero — it's just much slower than the 2.3-3.0 lbs/week she was losing before.

Psychologically, going from 3 lbs/week to 0.6 lbs/week feels like a plateau even though progress is technically still happening. This is why I always recommend plotting a 7-day moving average rather than looking at individual weigh-ins. Daily weight fluctuations of 2-4 lbs are completely normal due to water, sodium, and digestive contents.

41 12Dr.PulmRoch, maya_sedona, stefan_berlin and 38 others
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