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ForumsDosing & ProtocolsSteady-state concentrations across dose tiers — anyone have experience? Page 2

Steady-state concentrations across dose tiers — anyone have experience?

Dr.ReproEndo Mon, Jun 23, 2025 at 2:39 PM 47 replies 1,788 viewsPage 2 of 10
LibrarianMeg
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Jun 23, 2025 at 5:29 PM#6
PharmacoVig_BOS said:
— in my experience this comes down to a few key factors

Gonna push back on this one. Steady-state concentrations across is not that straightforward in my experience. I have been on this for 12 months and the reality is messier than the trials suggest.

Don't get me wrong — the medication works. But cost accessibility is a real barrier. We should be honest about that.

47 8Dr.NateNeph, PharmD_Rodriguez, julia.endo and 44 others
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dave_SLC
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Salt Lake City, UT
Jun 23, 2025 at 5:46 PM#7

Adding my data to this Steady-state discussion:

MetricBaselineMonth 5Month 6
Weight252 lbs242 lbs197 lbs
A1C6.6%6.0%5.2%
hsCRP6.04.01.0

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

21 9NicoleRaleigh, james_edin, FranDenver and 18 others
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LeilaHI
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Jun 23, 2025 at 6:03 PM#8

PharmD_Rodriguez — wow. This community is amazing.

11 6mike_nyc, VendorMark, COA_Karl and 8 others
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COA_Karl
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Pennsylvania
Jun 23, 2025 at 6:20 PM#9

Slightly tangential to Steady-state but FitDadDave reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

18 17tommy_boulder, hyun_seoul, jim_asheville and 15 others
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mike_mod
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Jun 23, 2025 at 6:37 PM#10

Moderator note: Please keep vendor-specific discussions in the Vendor Reviews section.

I have cleaned up a few off-topic posts. 👍

46 12PurityPaulOR, MaxMetOK, MounjBrad and 43 others
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