LibrarianMeg said:Steady-state concentrations across is not that straightforward in my experience
This is exactly right. LibrarianMeg articulated what I have been trying to explain to my doctor for months. The Steady-state aspect is the most important factor.
Reading this thread on Steady-state hits close to home. Night shift nurse — I started at 267 lbs and felt like I would tried everything.
13 months on tirz and I am a different person. Not just the 42 lbs lost — my energy, my mood, my relationship with food. All transformed.
If you are on the fence about Steady-state — take the leap. It was the best health decision I have ever made. ❤️
PharmD_Rodriguez — that is really helpful context on Steady-state. Follow-up question: what labs did your doctor order to monitor this?
I am in a similar situation (just started) and trying to set realistic expectations.
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View ResultsTo answer pat_auckland's question specifically:
From a clinical standpoint, Steady-state concentrations is an area where we have good evidence.
The short answer: baseline labs + quarterly monitoring is the standard of care.
The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.