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ForumsDosing & ProtocolsSteady-state concentrations across dose tiers — anyone have experience? Page 4

Steady-state concentrations across dose tiers — anyone have experience?

Dr.ReproEndo Mon, Jun 23, 2025 at 2:39 PM 47 replies 1,788 viewsPage 4 of 10
Dr.ReproEndo
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Jun 23, 2025 at 8:19 PM#16

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Steady-state.

To answer pat_auckland: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

35 12mona_PHX, andrew_nyc, Dr.EndoEP and 32 others
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BethLabQueen
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Jun 23, 2025 at 8:36 PM#17

Adding my data to this Steady-state discussion:

MetricBaselineMonth 3Month 8
Weight242 lbs237 lbs207 lbs
A1C6.6%5.8%5.4%
hsCRP6.02.00.8

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

16 4Dr.PulmRoch, maya_sedona, stefan_berlin and 13 others
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anna.melb_AU
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Jun 23, 2025 at 8:53 PM#18

Agreed. My doctor said the same thing about Steady-state.

Last edited: Jun 24, 2025 at 12:53 AM
11 5emma_london, tammy_FL, Dr.LipidDallas and 8 others
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BenResearch_OR
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Jun 23, 2025 at 9:10 PM#19

Slightly tangential to Steady-state but mark_tokyo reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

28 12Dr.KarenChen, Dr.NateNeph, PharmD_Rodriguez and 25 others
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Dr.PeteFamMed
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Jun 23, 2025 at 9:27 PM#20

+1 to Dr.ReproEndo. Especially the point about "Thank you all for the thoughtful replies..." — I have seen the same in my own experience with Steady-state.

17 22FranDenver, Dr.BariatricHTX, LindaRN_retired and 14 others
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