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ForumsDosing & ProtocolsSteady-state concentrations across dose tiers — anyone have experience? Page 6

Steady-state concentrations across dose tiers — anyone have experience?

Dr.ReproEndo Mon, Jun 23, 2025 at 2:39 PM 47 replies 1,788 viewsPage 6 of 10
JenMemphis
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Jun 23, 2025 at 11:09 PM#26

+1. This mirrors my journey exactly. The Steady-state discussion here is so valuable.

Last edited: Jun 24, 2025 at 4:09 AM
35 5MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 32 others
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DanielChem_CHI
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Mar 2024
Chicago, IL
Jun 23, 2025 at 11:26 PM#27
roxy_nash said:
Dad of 2 checking in — I started at 297 lbs and felt like I would tried everything

I respect roxy_nash perspective but I think this oversimplifies things a bit. Re: Steady-state concentrations — the subgroup analyses show meaningful heterogeneity.

I am not saying roxy_nash wrong entirely — just that the picture is more nuanced than a blanket statement. The SURMOUNT data specifically shows baseline BMI-dependent responses.

6 0Dr.DermMIA, fiona_VT, denise_HTX and 3 others
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andrew_nyc
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Apr 2024
New York, NY
Jun 23, 2025 at 11:43 PM#28

Reading this thread on Steady-state hits close to home. Night shift nurse — I started at 283 lbs and felt like I would tried everything.

9 months on tirz and I am a different person. Not just the 58 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Steady-state — take the leap. It was the best health decision I have ever made. ❤️

Last edited: Jun 24, 2025 at 4:43 AM
26 11PharmD_Rodriguez, julia.endo, JessicaM_2024 and 23 others
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kim_atl_prep
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Aug 2024
Atlanta, GA
Jun 24, 2025 at 12:00 AM#29

Bookmarked 📌 The Steady-state info in this thread is essential. Coming back to this for sure.

2 18SleepDoc_PDX, RegAffairsDC
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Dr.LeslieOBGYN
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May 2024
Dallas, TX
Jun 24, 2025 at 12:17 AM#30

JenMemphis — that is really helpful context on Steady-state. Follow-up question: did you change anything about your diet at the same time?

I am in a similar situation (month 2) and trying to set realistic expectations.

35 2mike_mealprep, NicoleRaleigh, james_edin and 32 others
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