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ForumsPharmacology & MechanismsGLP-1R expression map — 12 month update Page 5

GLP-1R expression map — 12 month update

DanielChem_CHI Tue, Jan 20, 2026 at 1:45 PM 28 replies 903 viewsPage 5 of 6
kevin_tulsa
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Jun 2024
Tulsa, OK
Jan 20, 2026 at 8:50 PM#21

Reading this thread on GLP-1R expression map 12 hits close to home. Night shift nurse — I started at 283 lbs and felt like I would tried everything.

9 months on tirz and I am a different person. Not just the 58 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about GLP-1R expression — take the leap. It was the best health decision I have ever made. ❤️

31 14fiona_glasgow, Dr.RheumBOS, greg_boulder and 28 others
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Dr.PulmRoch
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456
2,345
Jun 2024
Rochester, MN
Jan 20, 2026 at 9:07 PM#22

Adding my data to this GLP-1R expression map 12 discussion:

MetricBaselineMonth 3Month 8
Weight254 lbs249 lbs219 lbs
A1C6.8%5.8%5.4%
hsCRP8.02.01.2

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

46 3traveltech_sara, AttorneyGrant, DebRD_ATL and 43 others
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ben_calgary
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245
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Oct 2024
Calgary, CA
Jan 20, 2026 at 9:24 PM#23

Reading this thread on GLP-1R expression map 12 hits close to home. Dad of 2 checking in — I started at 265 lbs and felt like I would tried everything.

11 months on tirz and I am a different person. Not just the 40 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about GLP-1R expression — take the leap. It was the best health decision I have ever made. ❤️

22 12ZaraB_AL, JakeSmashed95, NauseaFreeNow and 19 others
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B12Beth
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289
890
Oct 2024
Maryland
Jan 20, 2026 at 9:41 PM#24

ben_calgary — that is really helpful context on GLP-1R expression map 12. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

18 5marco_milano, pam_columbus, nick_SD_fit and 15 others
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KetoKyle
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678
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Jul 2024
Utah
Jan 20, 2026 at 9:58 PM#25

Reading this thread on GLP-1R expression map 12 hits close to home. Night shift nurse — I started at 287 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 62 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about GLP-1R expression — take the leap. It was the best health decision I have ever made. ❤️

44 18JakeBK_lifts, DerekSJ_a1c, paige_pharma and 41 others
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