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ForumsDosing & ProtocolsDose-response curves — what worked for you? Page 3

Dose-response curves — what worked for you?

Dr.PathRoch Sat, May 3, 2025 at 7:01 PM 13 replies 1,404 viewsPage 3 of 3
PharmHunterJen
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567
2,345
Jul 2024
Illinois
May 3, 2025 at 11:16 PM#11

marcus_mpls — wow. I've been looking for this exact info for weeks.

Last edited: May 4, 2025 at 5:16 AM
45 17Dr.LipidDallas, alex_tucson, kevin_tulsa and 42 others
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lisa_labSD
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278
1,234
Oct 2024
San Diego, CA
May 3, 2025 at 11:33 PM#12

Slightly tangential to Dose-response curves but Dr.PathRoch reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

46 5maya_sedona, stefan_berlin, Dr.EM_Chicago and 43 others
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tommy_boulder
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1,123
Nov 2024
Boulder, CO
May 3, 2025 at 11:50 PM#13

Thanks for sharing this, Dr.PathRoch. A few questions about your Dose-response curves experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about Dose-response?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

41 13robert_kc, dan_philly, MeganSA_TX and 38 others
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Dr.PathRoch
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456
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Jun 2024
Rochester, MN
May 4, 2025 at 12:07 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Dose-response curves .

To answer lisa_labSD: I get my labs done through Quest every 3 months.

Quick update: my latest labs came back even better. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

17 11SaraMom3, Dr.MetabolicMD, RetaRick_CA and 14 others
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dave_SLC
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Aug 2024
Salt Lake City, UT
May 4, 2025 at 12:24 AM#15

Relevant to Dose-response curves what — here is my latest bloodwork comparison:

Key improvements: A1C 8.0% → 5.3%, triglycerides 235 → 105 mg/dL, hsCRP 6.0 → 1.1 mg/L. All on tirzepatide for 15 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

Last edited: May 4, 2025 at 4:24 AM
33 9Dr.BariatricHTX, LindaRN_retired, tommy_boulder and 30 others
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