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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsGLP-1/GIP receptor co-agonism — anyone have experience? Page 3

GLP-1/GIP receptor co-agonism — anyone have experience?

Dr.NephBHM_UK Mon, Jan 5, 2026 at 2:36 AM 36 replies 1,378 viewsPage 3 of 8
Dr.RheumBOS
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2,345
Apr 2024
Boston, MA
Jan 5, 2026 at 6:51 AM#11

Thank you quinn_sf! This is incredibly helpful. Bookmarking for later. 🙏

Last edited: Jan 5, 2026 at 12:51 PM
37 9pam_stl, wei_SG, cory_ATX and 34 others
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jennifer_SEA
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890
Nov 2024
Seattle, WA
Jan 5, 2026 at 7:08 AM#12

Slightly tangential to GLP-1/GIP receptor but Dr.NephBHM_UK reminded me — has the insurance landscape changed recently?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

44 16Dr.ReproEndo, lucas_SP_BR, lisa_labSD and 41 others
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RickReta_CO
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312
1,234
Jan 2025
Colorado
Jan 5, 2026 at 7:25 AM#13

Thanks for sharing this, Dr.NephBHM_UK. A few questions about your GLP-1/GIP receptor experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about GLP-1/GIP recep?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

38 17hyun_seoul, jim_asheville, matt_MKE and 35 others
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Dr.NephBHM_UK
Member
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Jun 2024
Birmingham, UK
Jan 5, 2026 at 7:42 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on GLP-1/GIP receptor.

To answer jennifer_SEA: my doctor and I discussed the options and went with brand.

Quick update: I have noticed more improvement since posting this. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Last edited: Jan 5, 2026 at 1:42 PM
15 19SurmountFan_IN, PeptideChemSF, A1cHero_PHX and 12 others
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dan_philly
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Jul 2024
Philadelphia, PA
Jan 5, 2026 at 7:59 AM#15

Adding my data to this GLP-1/GIP receptor discussion:

MetricBaselineMonth 3Month 6
Weight252 lbs237 lbs207 lbs
A1C6.6%5.8%5.2%
hsCRP6.02.01.0

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.4g/kg/day.

26 9EndoResFellow, PharmacoVig_BOS, SurmountFan_IN and 23 others
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