Just wanted to say — for anyone reading this GLP-1/GIP receptor thread who is feeling discouraged: it gets better. The first 6 weeks are the hardest. Hang in there. 💪

Slightly tangential to GLP-1/GIP receptor but mike_mod reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Exactly this. My pharmacist said the same thing about GLP-1/GIP receptor.

Want to share my personal experience related to GLP-1/GIP receptor co-agonism since I think it might help others in a similar situation.

I started my GLP-1 journey in March 2025 at 271 lbs with metabolic syndrome. My telehealth provider prescribed semaglutide 0.25mg to start.

Now, 14 months later: I am down 41 lbs, my labs have normalized, and my sleep apnea has improved dramatically. The GLP-1/GIP receptor aspect specifically was something that made a big difference in my journey.

This forum was my go-to resource throughout.

Clinical perspective on GLP-1/GIP receptor co-agonism anyone:

I have managed ~150 patients on GLP-1 therapy and this topic comes up frequently. What the data shows — and what I see in practice — is that the medication works best as part of a comprehensive approach.

For this specific question, I would recommend: getting comprehensive baseline labs first.