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ForumsPharmacology & MechanismsEnteroendocrine L-cell biology — what worked for you? Page 3

Enteroendocrine L-cell biology — what worked for you?

ZaraB_AL Tue, Dec 9, 2025 at 4:18 AM 11 replies 925 viewsPage 3 of 3
MounjBrad
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278
890
Oct 2024
Kentucky
Dec 9, 2025 at 8:33 AM#11

SkepticalSean — wow. This community is amazing.

44 1patPC_UT, Dr.DermMIA, fiona_VT and 41 others
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Dr.EM_Chicago
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567
2,567
May 2024
Chicago, IL
Dec 9, 2025 at 8:50 AM#12

Slightly tangential to Enteroendocrine L-cell but ZaraB_AL reminded me — what is the latest on the oral formulations?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

18 22matt_MKE, Dr.ReproEndo, lucas_SP_BR and 15 others
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lucas_SP_BR
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1,890
Jun 2024
São Paulo, BR
Dec 9, 2025 at 9:07 AM#13

Thanks for sharing this, ZaraB_AL. A few questions about your Enteroendocrine experience:

  1. What dose did you start at?
  2. How long before you noticed side effects improving?
  3. Did your provider have any specific recommendations about Enteroendocrine?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

Last edited: Dec 9, 2025 at 11:07 AM
31 3zoe_NC, Dr.ObesityLA, NurseKim_ATL and 28 others
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ZaraB_AL
Member
456
1,678
Jan 2025
Alabama
Dec 9, 2025 at 9:24 AM#14

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Enteroendocrine L-cell.

To answer Dr.EM_Chicago: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

2 11TrialTracker_MD, JennaRN
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Dr.PulmRoch
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2,345
Jun 2024
Rochester, MN
Dec 9, 2025 at 9:41 AM#15

Relevant to Enteroendocrine L-cell biology — here is my latest bloodwork comparison:

Key improvements: A1C 8.4% → 5.5%, triglycerides 205 → 105 mg/dL, hsCRP 8.0 → 1.1 mg/L. All on tirzepatide for 9 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.

41 17KristenIndy, MarkLI_maint, Dr.PeteFamMed and 38 others
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