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ForumsMetabolic Health & DiabetesAdiponectin and leptin changes on GLP-1 therapy — my results so far Page 2

Adiponectin and leptin changes on GLP-1 therapy — my results so far

rachel_ABQ Fri, Jan 16, 2026 at 5:12 AM 12 replies 812 viewsPage 2 of 3
HealthEcon_DC
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Jan 16, 2026 at 8:02 AM#6

The sleep piece resonates hard with me. I'm a nurse doing 12-hour night shifts and my weight loss has been slower than most people I see posting here. I average about 5 hours of broken sleep on work days. I wonder how much that's holding me back.

Last edited: Jan 16, 2026 at 10:02 AM
10 6NeuroNate, JessicaH_TX, KevinCompounds and 7 others
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Dr.PathRoch
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Jan 16, 2026 at 8:19 AM#7

Sleep deprivation is enormously underappreciated as a factor in weight management. There are studies showing that people in a caloric deficit who sleep 5.5 hours lose 55% less fat and 60% more lean mass compared to those sleeping 8.5 hours — same caloric intake. Shift workers consistently show higher rates of obesity, metabolic syndrome, and cardiovascular disease, and disrupted circadian rhythm is a major contributor.

I know you can't always control your schedule, but even small improvements — blackout curtains, consistent wake times on days off, limiting caffeine 8+ hours before sleep — can help.

8 17InsuranceTom, WendyG_ATL, SaraMom3 and 5 others
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Dr.RaviCardio
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Jan 16, 2026 at 8:36 AM#8

Looking at the OP's numbers from a trends perspective: the "plateau" from week 14-19 actually shows a slight downward trend if you plot it. 222 → 219 over 5 weeks is about 0.6 lbs/week. That's not zero — it's just much slower than the 2.3-3.0 lbs/week she was losing before.

Psychologically, going from 3 lbs/week to 0.6 lbs/week feels like a plateau even though progress is technically still happening. This is why I always recommend plotting a 7-day moving average rather than looking at individual weigh-ins. Daily weight fluctuations of 2-4 lbs are completely normal due to water, sodium, and digestive contents.

16 8mark_tokyo, hans_munich, jason_sac26 and 13 others
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