My endo and I disagree about best time of day to inject? and I want a reality check.

They are saying that I do not need to worry about it but everything I have read here suggests otherwise.

I trust this community's collective knowledge but I also do not want to go against medical advice without good reason. What would you do?

HealthEcon_DC's experience with Best time of day to resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 68 lbs in 13 months.

One thing I would add that HealthEcon_DC did not mention: the relationship with food fundamentally changed.

Thanks for sharing this, HealthEcon_DC. A few questions about your Best time of day to experience:

1. What dose worked best for you?
2. How long before you noticed appetite suppression kicking in?
3. Did your endo have any specific recommendations about Best time of?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Best time of day to.

To answer cory_ATX: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Relevant to Best time of day to inject? I — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 221 → 91 mg/dL, hsCRP 8.0 → 0.9 mg/L. All on tirzepatide for 13 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.