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ForumsMetabolic Health & DiabetesHOMA-IR tracking on GLP-1 — need advice Page 3

HOMA-IR tracking on GLP-1 — need advice

NurseLeah_Nash Wed, Dec 31, 2025 at 6:07 AM 14 replies 762 viewsPage 3 of 3
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Dec 31, 2025 at 10:22 AM#11

Moderator note: Reminder: nothing posted here constitutes medical advice. Consult your healthcare provider.

Tagging this for the weekly digest. 👍

Last edited: Dec 31, 2025 at 2:22 PM
9 22PedsEndoPhilly, SleepDoc_PDX, RegAffairsDC and 6 others
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Dr.SurgeonPGH
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Dec 31, 2025 at 10:39 AM#12

Slightly tangential to HOMA-IR tracking on GLP-1 but Dr.ObesityLA reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

24 14TomTeleRx, DoseLogDan, SleepFixSam and 21 others
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andrew_nyc
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Dec 31, 2025 at 10:56 AM#13
KarenAZ_mom said:
Follow-up question: how long did you wait before increasing your dose

This is exactly right. KarenAZ_mom articulated what I have been trying to explain to my doctor for months. The HOMA-IR tracking on GLP-1 aspect is the most important factor.

8 20PharmD_Rodriguez, julia.endo, JessicaM_2024 and 5 others
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kim_atl_prep
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Dec 31, 2025 at 11:13 AM#14

Saving this for reference. Top-tier content.

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Dr.AddMedPHL
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Dec 31, 2025 at 11:30 AM#15

Adding my data to this HOMA-IR tracking on GLP-1 discussion:

MetricBaselineMonth 5Month 8
Weight270 lbs225 lbs215 lbs
A1C6.4%6.0%5.4%
hsCRP4.04.01.2

Protocol: Semaglutide 1.7mg/wk, resistance training 3x/wk, protein 1.2g/kg/day.

37 15JessicaM_2024, TomFromTexas, mike.trainer_LA and 34 others
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