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ForumsDosing & ProtocolsSemaglutide PK modeling — anyone have experience? Page 2

Semaglutide PK modeling — anyone have experience?

anna.melb_AU Tue, Nov 5, 2024 at 11:07 AM 31 replies 2,196 viewsPage 2 of 7
DebRD_ATL
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Nov 5, 2024 at 1:57 PM#6

Quick practical note — if you're doing 0.125mg from a compounded vial, the reconstitution math matters a lot here. With a 5mg vial:

  • Add 2mL BAC water → 2.5mg/mL → 0.125mg = 0.05mL = 5 units

5 units on an insulin syringe is a very small amount — just be sure you're using a syringe with fine enough markings. A 0.3mL (30-unit) syringe will have individual unit markings and be much easier to read accurately at this volume than a full 1mL syringe.

43 2BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 40 others
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patPC_UT
Member
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Nov 2024
Park City, UT
Nov 5, 2024 at 2:14 PM#7

Great call on the syringe. I'll order the 0.3mL ones. Thank you for the advice! 🙏

Last edited: Nov 5, 2024 at 7:14 PM
5 22mike.trainer_LA, sarah_nash92, FitDadDave and 2 others
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TrialNerd_Beth
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Bethesda, MD
Nov 5, 2024 at 2:31 PM#8

Good discussion. I'll just add the standard disclaimer that micro-dosing is off-label and should be done under provider supervision. We don't want anyone reading this thread and deciding to start at a random low dose without medical guidance. Your provider can factor in your full medical history, not just your weight.

40 4TomTeleRx, DoseLogDan, SleepFixSam and 37 others
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