Thank you Dr.RheumBOS! This is incredibly helpful. Taking this to my next appointment. 🙏

Slightly tangential to Tachyphylaxis vs but FranDenver reminded me — does anyone have experience combining this with metformin?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

Thanks for sharing this, FranDenver. A few questions about your Tachyphylaxis vs experience:

1. What dose did you start at?
2. How long before you noticed side effects improving?
3. Did your provider have any specific recommendations about Tachyphylaxis?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Tachyphylaxis vs.

To answer Dr.LeslieOBGYN: I started tracking everything in a spreadsheet from day 1.

Quick update: I will post a proper update thread soon. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Adding my data to this Tachyphylaxis vs discussion:

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.3g/kg/day.