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ForumsDosing & ProtocolsSteady-state concentrations across dose tiers — January 2024 Page 3

Steady-state concentrations across dose tiers — January 2024

Dr.GastroMayo Mon, Sep 9, 2024 at 11:53 AM 11 replies 1,654 viewsPage 3 of 3
adam_van
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Sep 9, 2024 at 4:08 PM#11
anders_CPH said:
Steady-state concentrations across is not that straightforward in my experience

This is exactly right. anders_CPH articulated what I have been trying to explain to my friends for months. The Steady-state aspect is what made the difference for me.

36 13FranDenver, Dr.BariatricHTX, LindaRN_retired and 33 others
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sean_dublin
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Dublin, IE
Sep 9, 2024 at 4:25 PM#12

Reading this thread on Steady-state hits close to home. Dad of 2 checking in — I started at 293 lbs and felt like I would tried everything.

9 months on tirz and I am a different person. Not just the 68 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Steady-state — take the leap. It was the best health decision I have ever made. ❤️

37 22sean_dublin, hannah_MT, Dr.SportsMedIN and 34 others
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A1cHero_PHX
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Phoenix, AZ
Sep 9, 2024 at 4:42 PM#13

SleepDoc_PDX — that is really helpful context on Steady-state. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

25 16tampaLisa73, KarenAZ_mom, zoe_NC and 22 others
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SleepDoc_PDX
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Sep 9, 2024 at 4:59 PM#14

To answer sean_dublin's question specifically:

From a clinical standpoint, Steady-state concentrations is a reasonable concern that deserves a thorough answer.

The short answer: the evidence supports this approach for most patients.

The longer answer involves reviewing the specific clinical trial data relevant to your question, which I am happy to elaborate on if helpful.

Last edited: Sep 9, 2024 at 7:59 PM
46 22sophie_paris, mel_PDX, Dr.AddMedPHL and 43 others
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nick_newbie
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Sep 9, 2024 at 5:16 PM#15

Bookmarked 📌 The Steady-state info in this thread is essential. Coming back to this for sure.

47 1wanda_boise, NurseAsh_DET, BenResearch_OR and 44 others
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