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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsPeptide degradation pathways — anyone have experience? Page 5

Peptide degradation pathways — anyone have experience?

lori_vegas Sat, Aug 23, 2025 at 12:24 PM 26 replies 1,236 viewsPage 5 of 6
carlos_SATX
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Oct 2024
San Antonio, TX
Aug 23, 2025 at 7:29 PM#21

Reading this thread on Peptide degradation hits close to home. Night shift nurse — I started at 263 lbs and felt like I would tried everything.

9 months on tirz and I am a different person. Not just the 38 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Peptide degradation — take the leap. It was the best health decision I have ever made. ❤️

46 9james_edin, FranDenver, Dr.BariatricHTX and 43 others
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Dr.PathRoch
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Jun 2024
Rochester, MN
Aug 23, 2025 at 7:46 PM#22

Adding my data to this Peptide degradation discussion:

MetricBaselineMonth 3Month 8
Weight274 lbs224 lbs219 lbs
A1C6.8%5.8%5.4%
hsCRP8.02.00.8

Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.

46 21InsuranceTom, WendyG_ATL, SaraMom3 and 43 others
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TomTeleRx
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678
Feb 2025
Delaware
Aug 23, 2025 at 8:03 PM#23

Reading this thread on Peptide degradation hits close to home. Dad of 2 checking in — I started at 285 lbs and felt like I would tried everything.

11 months on tirz and I am a different person. Not just the 60 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Peptide degradation — take the leap. It was the best health decision I have ever made. ❤️

3 1LibrarianMeg, bri_stats, pete_manc_UK
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cory_ATX
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Jul 2024
Austin, TX
Aug 23, 2025 at 8:20 PM#24

TomTeleRx — that is really helpful context on Peptide degradation. Follow-up question: how long did you wait before increasing your dose?

I am in a similar situation (week 4) and trying to set realistic expectations.

Last edited: Aug 23, 2025 at 10:20 PM
18 22Dr.PathRoch, mona_PHX, andrew_nyc and 15 others
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MikeKY_noInsulin
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1,234
Oct 2024
Louisville, KY
Aug 23, 2025 at 8:37 PM#25

Reading this thread on Peptide degradation hits close to home. Night shift nurse — I started at 267 lbs and felt like I would tried everything.

13 months on tirz and I am a different person. Not just the 42 lbs lost — my energy, my mood, my relationship with food. All transformed.

If you are on the fence about Peptide degradation — take the leap. It was the best health decision I have ever made. ❤️

Last edited: Aug 23, 2025 at 11:37 PM
43 3bbq_ray_KC, oliver_london, tane_welly and 40 others
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