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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMetabolic Health & DiabetesGLP-1 and beta-cell preservation — 12 month update Page 2

GLP-1 and beta-cell preservation — 12 month update

PeptideSynthNJ Thu, Oct 2, 2025 at 4:58 AM 7 replies 1,011 viewsPage 2 of 2
mike_nyc
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Oct 2, 2025 at 7:48 AM#6

Saving this for reference. Quality thread.

17 15maya_sedona, stefan_berlin, Dr.EM_Chicago and 14 others
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julia.endo
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Oct 2, 2025 at 8:05 AM#7

Slightly tangential to GLP-1 and beta-cell but wendy_avl reminded me — has anyone else noticed changes in their alcohol tolerance?

I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.

40 22mark_tokyo, hans_munich, jason_sac26 and 37 others
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Dr.ReproEndo
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Oct 2, 2025 at 8:22 AM#8

+1 to wendy_avl. Especially the point about "A few questions about your GLP-1 and bet..." — I have seen the same in my own experience with GLP-1 and beta-cell.

Last edited: Oct 2, 2025 at 9:22 AM
24 22Dr.EndoEP, GraceAZ_72, carl_compliance and 21 others
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SkepticalSean
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Oct 2, 2025 at 8:39 AM#9

Dr.LeslieOBGYN — that is really helpful context on GLP-1 and beta-cell. Follow-up question: what labs did your doctor order to monitor this?

I am in a similar situation (just started) and trying to set realistic expectations.

49 18tammy_FL, Dr.LipidDallas, alex_tucson and 46 others
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Dr.SportsMedIN
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Oct 2, 2025 at 8:56 AM#10

To answer Dr.ReproEndo's question specifically:

From a clinical standpoint, GLP-1 and beta-cell is an area where we have good evidence.

The short answer: baseline labs + quarterly monitoring is the standard of care.

The longer answer involves understanding the mechanism of action at the receptor level, which I am happy to elaborate on if helpful.

15 21rachel_ABQ, traveltech_sara, AttorneyGrant and 12 others
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