My endo and I disagree about drawing from a multi-dose vial anyone and I want a reality check.

They are saying that I do not need to worry about it but everything I have read here suggests otherwise.

I trust this community's collective knowledge but I also do not want to go against medical advice without good reason. What would you do?

raj_cambridge's experience with Drawing from a multi-dose resonates deeply with mine. I went through almost the identical process — starting dose, titration timeline, side effects, everything.

The main difference: I titrated faster. But the overall trajectory has been remarkably similar. Down 36 lbs in 11 months.

One thing I would add that raj_cambridge did not mention: the relationship with food fundamentally changed.

Thanks for sharing this, raj_cambridge. A few questions about your Drawing from a experience:

1. What dose are you currently on?
2. How long before you noticed significant changes?
3. Did your doctor have any specific recommendations about Drawing from a?

I am in a similar boat and trying to learn from others' experiences before my next appointment.

OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Drawing from a multi-dose.

To answer Dr.GastroMayo: yes, I am on compounded sema from a 503B pharmacy.

Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏

Relevant to Drawing from a multi-dose vial — here is my latest bloodwork comparison:

Key improvements: A1C 7.6% → 5.5%, triglycerides 249 → 119 mg/dL, hsCRP 8.0 → 1.3 mg/L. All on tirzepatide for 17 months.

The inflammatory marker drop is what impresses me most. Consistent with the SELECT trial's cardiovascular findings.