To answer CryptoCarl's question specifically:
From a clinical standpoint, Has anyone dealt with is something I discuss with patients regularly.
The short answer: discuss this specific situation with your prescribing provider.
The longer answer involves weighing the risk-benefit ratio for your individual situation, which I am happy to elaborate on if helpful.
Slightly tangential to Has anyone dealt with but CryptoCarl reminded me — does anyone have experience combining this with metformin?
I know it is not exactly on-topic but it seems related enough to ask here rather than starting a new thread. Apologies if this has been covered — I did search first.
OP here — wow, did not expect this much response! Thank you all for the thoughtful replies on Has anyone dealt with .
To answer Dr.MetabolicMD: yes, I am on compounded sema from a 503B pharmacy.
Quick update: things are still going well. Thanks again for the evidence-based discussion — this is exactly why I posted in a science-based community. 🙏
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Shop Reference StandardsReading this thread on Has anyone dealt with hits close to home. Night shift nurse — I started at 263 lbs and felt like I would tried everything.
9 months on tirz and I am a different person. Not just the 38 lbs lost — my energy, my mood, my relationship with food. All transformed.
If you are on the fence about Has anyone dealt — take the leap. It was the best health decision I have ever made. ❤️
Adding my data to this Has anyone dealt with discussion:
| Metric | Baseline | Month 3 | Month 8 |
|---|---|---|---|
| Weight | 274 lbs | 219 lbs | 219 lbs |
| A1C | 6.8% | 5.8% | 5.4% |
| hsCRP | 8.0 | 2.0 | 0.8 |
Protocol: Semaglutide 2.4mg/wk, resistance training 3x/wk, protein 1.6g/kg/day.