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Evidence-based GLP-1 & peptide discussion since 2023
Forumsβ€ΊOff-Topicβ€ΊI fit into my college jeans and I am not okay (happy tears)

I fit into my college jeans and I am not okay (happy tears)

JenMemphis Fri, Jan 16, 2026 at 7:00 AM 27 replies 986 viewsPage 1 of 6
JenMemphis
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Jan 16, 2026 at 8:25 AM#1

Just had to share this with someone who would understand β€” i fit into my college jeans.

Got my latest A1C and I am genuinely emotional right now. 12 months in and the progress is real.

Details in the comments but wanted to start this thread because I think others going through the same thing need to see that it works.

12 18MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 9 others
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DebRD_ATL
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Jan 16, 2026 at 8:42 AM#2
JenMemphis said:
I fit into my college jeans and I am not okay (happy tears)

I respect JenMemphis perspective but I think this oversimplifies things a bit. Re: I fit into my college jeans β€” the subgroup analyses show meaningful heterogeneity.

I am not saying JenMemphis wrong entirely β€” just that the picture is more nuanced than a blanket statement. The SURMOUNT data specifically shows baseline BMI-dependent responses.

Last edited: Jan 16, 2026 at 12:42 PM
44 13RegAffairsDC, BiostatsBrad, PeptideSynthNJ and 41 others
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quinn_sf
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San Francisco, CA
Jan 16, 2026 at 8:59 AM#3

+1 to JenMemphis. Especially the point about "I fit into my college jeans and I am not..." β€” I have seen the same in my own experience with I fit into my college.

17 2mona_PHX, andrew_nyc, Dr.EndoEP and 14 others
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Dr.MetabolicMD
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Jan 16, 2026 at 9:16 AM#4

As a pharmacist, I want to add some clinical context to this discussion on I fit into my college jeans and I am not.

Building on what JenMemphis said β€” the evidence base here is robust. The key publications to reference are from the FLOW program[1].

Key clinical points:

  1. Efficacy is dose-dependent and typically requires 4-5 weeks to reach steady state
  2. Side effect profile is predictable and usually manageable with standard protocols
  3. Monitoring should include baseline labs and follow-up at 3-month intervals
  4. Patient education significantly improves outcomes and adherence

Standard disclaimer: this is educational, not individualized medical advice.

References:
[1] See thread title for relevant study identification.
24 19Dr.ObesityMed, HealthEcon_DC, PedsEndoPhilly and 21 others
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Dr.RaviCardio
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Jan 16, 2026 at 9:33 AM#5
quinn_sf said:
Especially the point about "I fit into my college jeans and I am not

Gonna push back on this one. I fit into my college jeans and I is not that straightforward in my experience. I have been on this for 12 months and the reality is messier than the trials suggest.

Don't get me wrong β€” the medication works. But cost accessibility is a real barrier. We should be honest about that.

18 11jason_sac26, chris_chi24, tampaLisa73 and 15 others
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